Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/ParE-CC2985
Location 2811..3360 Replicon plasmid pHNAH8130-1
Accession NZ_CP104927
Organism Klebsiella pasteurii strain AHM8C130-1I

Toxin (Protein)


Gene name PrpT Uniprot ID -
Locus tag N5863_RS28995 Protein ID WP_284659166.1
Coordinates 2811..3107 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID -
Locus tag N5863_RS29000 Protein ID WP_284659167.1
Coordinates 3094..3360 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5863_RS28985 (N5863_28980) 1..1011 + 1011 WP_000200070.1 RepB family plasmid replication initiator protein -
N5863_RS28990 (N5863_28985) 1709..2449 - 741 WP_284659165.1 tyrosine-type recombinase/integrase -
N5863_RS28995 (N5863_28990) 2811..3107 - 297 WP_284659166.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5863_RS29000 (N5863_28995) 3094..3360 - 267 WP_284659167.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
N5863_RS29005 (N5863_29000) 3571..3959 - 389 Protein_4 transposase -
N5863_RS29010 (N5863_29005) 4326..5243 + 918 WP_284659168.1 winged helix-turn-helix domain-containing protein -
N5863_RS29015 (N5863_29010) 5377..5940 + 564 WP_284659169.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..92922 92922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11499.01 Da        Isoelectric Point: 6.3699

>T259517 WP_284659166.1 NZ_CP104927:c3107-2811 [Klebsiella pasteurii]
VKTVKLTPKASQDLEDIWYYGYHHFGEEQADKYINQISDIFQVVSDHNIGTPRPQLGEHICALPVERHMIYFLQTDTEIV
IIRILSQHQDAGRHLNWK

Download         Length: 297 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10013.36 Da        Isoelectric Point: 6.3783

>AT259517 WP_284659167.1 NZ_CP104927:c3360-3094 [Klebsiella pasteurii]
MARTMTVNLGDELRNFIESLIESGDYRTQSEVIRDSLRLLREKQAESRLQALRDLLAEGLSSGEPVTWEKDAFLKKVKAG
MRTSGENR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References