259514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 4772641..4773358 Replicon chromosome
Accession NZ_CP104925
Organism Klebsiella pasteurii strain AHM8C130-1I

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag N5863_RS22520 Protein ID WP_071994601.1
Coordinates 4773026..4773358 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8B4G4X8
Locus tag N5863_RS22515 Protein ID WP_032410127.1
Coordinates 4772641..4772991 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5863_RS22485 (N5863_22480) 4767818..4768969 - 1152 WP_284658635.1 hypothetical protein -
N5863_RS22490 (N5863_22485) 4769067..4769960 + 894 WP_032410131.1 50S ribosome-binding GTPase -
N5863_RS22495 (N5863_22490) 4770245..4770922 + 678 WP_032410130.1 hypothetical protein -
N5863_RS22500 (N5863_22495) 4771018..4771839 + 822 WP_162897387.1 DUF932 domain-containing protein -
N5863_RS22505 (N5863_22500) 4771910..4772383 + 474 WP_032410128.1 DNA repair protein RadC -
N5863_RS22510 (N5863_22505) 4772399..4772620 + 222 WP_004129348.1 DUF987 domain-containing protein -
N5863_RS22515 (N5863_22510) 4772641..4772991 + 351 WP_032410127.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
N5863_RS22520 (N5863_22515) 4773026..4773358 + 333 WP_071994601.1 TA system toxin CbtA family protein Toxin
N5863_RS22525 (N5863_22520) 4773739..4774065 + 327 Protein_4429 Arm DNA-binding domain-containing protein -
N5863_RS22530 (N5863_22525) 4774089..4774622 + 534 Protein_4430 IS3 family transposase -
N5863_RS22535 (N5863_22530) 4774655..4776265 - 1611 WP_227631513.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4748954..4776265 27311
- flank IS/Tn - - 4774257..4774622 365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12513.46 Da        Isoelectric Point: 7.2132

>T259514 WP_071994601.1 NZ_CP104925:4773026-4773358 [Klebsiella pasteurii]
MNTLPAINQRAVQTCLSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVLKRHIEAGITLVDAVNFLVEKYELIRIDRRGF
SSQGQVPYLTVTDILHARRECGLTNSCPYR

Download         Length: 333 bp

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13014.93 Da        Isoelectric Point: 7.1865

>AT259514 WP_032410127.1 NZ_CP104925:4772641-4772991 [Klebsiella pasteurii]
MSSKTLTVNDDTAEPWWGLNRNVIPCFGARLVQEGNRLYYLSDRASIIGLFNKADLLRLDQAFPVLLKQAELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGHVYISIYPTQR

Download         Length: 351 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4G4X8

References