259507

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884271..884928 Replicon chromosome
Accession NZ_CP104925
Organism Klebsiella pasteurii strain AHM8C130-1I

Toxin (Protein)


Gene name cptA Uniprot ID H3N294
Locus tag N5863_RS04245 Protein ID WP_004124948.1
Coordinates 884518..884928 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag N5863_RS04240 Protein ID WP_004124953.1
Coordinates 884271..884537 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5863_RS04225 (N5863_04225) 879526..879951 - 426 WP_004124962.1 PTS sugar transporter subunit IIA -
N5863_RS04230 (N5863_04230) 880072..882870 - 2799 WP_004124960.1 transcriptional regulator DagR -
N5863_RS04235 (N5863_04235) 883043..884026 - 984 WP_004124956.1 tRNA-modifying protein YgfZ -
N5863_RS04240 (N5863_04240) 884271..884537 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
N5863_RS04245 (N5863_04245) 884518..884928 + 411 WP_004124948.1 protein YgfX Toxin
N5863_RS04250 (N5863_04250) 884937..885458 - 522 WP_004124946.1 flavodoxin FldB -
N5863_RS04255 (N5863_04255) 885580..886476 + 897 WP_284658846.1 site-specific tyrosine recombinase XerD -
N5863_RS04260 (N5863_04260) 886499..887212 + 714 WP_004124939.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N5863_RS04265 (N5863_04265) 887218..888951 + 1734 WP_004124937.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.88 Da        Isoelectric Point: 10.9455

>T259507 WP_004124948.1 NZ_CP104925:884518-884928 [Klebsiella pasteurii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT259507 WP_004124953.1 NZ_CP104925:884271-884537 [Klebsiella pasteurii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3N294

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References