Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1966117..1967705 Replicon chromosome
Accession NZ_CP104920
Organism Dickeya solani strain RNS 05.1.2A

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag RS71_RS08680 Protein ID WP_057083554.1
Coordinates 1966386..1967705 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2K8W0B1
Locus tag RS71_RS08675 Protein ID WP_022635524.1
Coordinates 1966117..1966386 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RS71_RS08650 1961434..1962045 - 612 WP_057083549.1 NAD(P)-dependent oxidoreductase -
RS71_RS08655 1962187..1962573 + 387 WP_057083550.1 helix-turn-helix domain-containing protein -
RS71_RS08660 1962672..1963757 - 1086 WP_057083551.1 4-hydroxyphenylpyruvate dioxygenase -
RS71_RS08665 1964073..1964846 + 774 WP_057083552.1 MBL fold metallo-hydrolase -
RS71_RS08670 1964890..1965846 + 957 WP_081020613.1 helix-turn-helix domain-containing protein -
RS71_RS08675 1966117..1966386 + 270 WP_022635524.1 helix-turn-helix domain-containing protein Antitoxin
RS71_RS08680 1966386..1967705 + 1320 WP_057083554.1 type II toxin-antitoxin system HipA family toxin Toxin
RS71_RS08685 1967777..1969141 - 1365 WP_057083555.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
RS71_RS08690 1969257..1970888 - 1632 WP_022635527.1 membrane protein insertase YidC -
RS71_RS08695 1970891..1971148 - 258 WP_071598660.1 membrane protein insertion efficiency factor YidD -
RS71_RS08700 1971112..1971471 - 360 WP_022635528.1 ribonuclease P protein component -
RS71_RS08705 1971490..1971630 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49105.17 Da        Isoelectric Point: 6.3476

>T259494 WP_057083554.1 NZ_CP104920:1966386-1967705 [Dickeya solani]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAQAVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSQLTTGWE

Download         Length: 1320 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9950.26 Da        Isoelectric Point: 10.0983

>AT259494 WP_022635524.1 NZ_CP104920:1966117-1966386 [Dickeya solani]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W0B1

References