Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 817649..819489 Replicon chromosome
Accession NZ_CP104920
Organism Dickeya solani strain RNS 05.1.2A

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag RS71_RS03795 Protein ID WP_057082938.1
Coordinates 818143..819489 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag RS71_RS03790 Protein ID WP_057082939.1
Coordinates 817649..818146 (-) Length 166 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RS71_RS03765 812966..813805 - 840 WP_057082943.1 MurR/RpiR family transcriptional regulator -
RS71_RS03770 813980..815569 + 1590 WP_057082942.1 gamma-glutamyltransferase family protein -
RS71_RS03775 815614..815811 + 198 WP_057082941.1 oxalurate catabolism protein HpxX -
RS71_RS03780 815808..817220 + 1413 WP_057082940.1 AtzE family amidohydrolase -
RS71_RS03785 817217..817597 + 381 WP_022634629.1 oxalurate catabolism protein HpxZ -
RS71_RS03790 817649..818146 - 498 WP_057082939.1 helix-turn-helix transcriptional regulator Antitoxin
RS71_RS03795 818143..819489 - 1347 WP_057082938.1 HipA domain-containing protein Toxin
RS71_RS03800 819746..820693 - 948 WP_057082937.1 allantoinase PuuE -
RS71_RS03805 820737..821474 - 738 WP_057082936.1 allantoin racemase -
RS71_RS03810 821471..822214 - 744 WP_057082935.1 GntR family transcriptional regulator -
RS71_RS03815 822367..823851 + 1485 WP_022634635.1 NCS1 family nucleobase:cation symporter-1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(89-142)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50555.31 Da        Isoelectric Point: 4.9663

>T259493 WP_057082938.1 NZ_CP104920:c819489-818143 [Dickeya solani]
MERLTVQAFIDNVWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGVRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

Antitoxin


Download         Length: 166 a.a.        Molecular weight: 18205.01 Da        Isoelectric Point: 10.6920

>AT259493 WP_057082939.1 NZ_CP104920:c818146-817649 [Dickeya solani]
MSQKRNNTTDVYAGADDVQETIRKLRQRVQERNVALEQMLRPPVITVAETADIPKARASKNSRPLNASERQSAMQSIIRR
MMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTLSEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILAT
APASR

Download         Length: 498 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References