Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1554531..1555117 Replicon chromosome
Accession NZ_CP104917
Organism Avibacterium paragallinarum strain AP-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N8E87_RS07695 Protein ID WP_264243865.1
Coordinates 1554531..1554779 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3G8VZN0
Locus tag N8E87_RS07700 Protein ID WP_035687072.1
Coordinates 1554776..1555117 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E87_RS07680 (N8E87_07680) 1550553..1551752 + 1200 WP_035688521.1 tyrosine--tRNA ligase -
N8E87_RS07685 (N8E87_07685) 1552072..1553001 + 930 WP_264243860.1 aminoimidazole riboside kinase -
N8E87_RS07690 (N8E87_07690) 1553020..1554471 + 1452 WP_264243862.1 glycoside hydrolase family 32 protein -
N8E87_RS07695 (N8E87_07695) 1554531..1554779 + 249 WP_264243865.1 type II toxin-antitoxin system HicA family toxin Toxin
N8E87_RS07700 (N8E87_07700) 1554776..1555117 + 342 WP_035687072.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N8E87_RS07705 (N8E87_07705) 1555212..1555688 + 477 WP_264243867.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
N8E87_RS07710 (N8E87_07710) 1555701..1556948 + 1248 WP_264243869.1 N-acetylmuramoyl-L-alanine amidase -
N8E87_RS07715 (N8E87_07715) 1556957..1558930 + 1974 WP_264243871.1 DNA mismatch repair endonuclease MutL -
N8E87_RS07720 (N8E87_07720) 1558939..1559865 + 927 WP_264243873.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9239.88 Da        Isoelectric Point: 10.2543

>T259491 WP_264243865.1 NZ_CP104917:1554531-1554779 [Avibacterium paragallinarum]
MGKSEKLLEKLANAKNTFIWTDLLTLLTRLGYEKREMTGSRVRFYNAELDHLILLHKPPPENYIKGGALKSVKEGLKGAG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12710.50 Da        Isoelectric Point: 4.5942

>AT259491 WP_035687072.1 NZ_CP104917:1554776-1555117 [Avibacterium paragallinarum]
MTLLKYKGYVGTIEADLENNVLFGKLAYIRDVITYEAETLPQLEKEFQTSVDLYLQDCQELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGDLSLNAFVAEAIKEKVERAGITN

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8VZN0

References