Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1070189..1071822 Replicon chromosome
Accession NZ_CP104917
Organism Avibacterium paragallinarum strain AP-2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N8E87_RS05395 Protein ID WP_264246476.1
Coordinates 1070189..1071496 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0F5F0S8
Locus tag N8E87_RS05400 Protein ID WP_046098117.1
Coordinates 1071496..1071822 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E87_RS05370 (N8E87_05370) 1065285..1066319 + 1035 WP_264246466.1 thiamine-phosphate kinase -
N8E87_RS05375 (N8E87_05375) 1066325..1066825 + 501 WP_264246467.1 phosphatidylglycerophosphatase A -
N8E87_RS05380 (N8E87_05380) 1066837..1067472 + 636 WP_264246470.1 LysE family transporter -
N8E87_RS05385 (N8E87_05385) 1067487..1068299 + 813 WP_264246472.1 4-hydroxy-tetrahydrodipicolinate reductase -
N8E87_RS05390 (N8E87_05390) 1069841..1070089 + 249 WP_264246474.1 class I ribonucleotide reductase maintenance protein YfaE -
N8E87_RS05395 (N8E87_05395) 1070189..1071496 + 1308 WP_264246476.1 HipA domain-containing protein Toxin
N8E87_RS05400 (N8E87_05400) 1071496..1071822 + 327 WP_046098117.1 helix-turn-helix domain-containing protein Antitoxin
N8E87_RS05405 (N8E87_05405) 1071863..1072993 - 1131 WP_017806521.1 class Ia ribonucleoside-diphosphate reductase subunit beta -
N8E87_RS05410 (N8E87_05410) 1073156..1073578 - 423 WP_264246479.1 DUF1043 family protein -
N8E87_RS05415 (N8E87_05415) 1073667..1075436 - 1770 WP_264246481.1 30S ribosomal protein S12 methylthiotransferase accessory factor YcaO -
N8E87_RS05420 (N8E87_05420) 1075543..1076274 - 732 WP_264246483.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 940449..1084743 144294


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-345)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50301.30 Da        Isoelectric Point: 5.8022

>T259489 WP_264246476.1 NZ_CP104917:1070189-1071496 [Avibacterium paragallinarum]
MEKLTLQTYIDQEWRDMAELHFEEETYQLSNLVYFPDYITQYFGQEGSRAVSINYPVHIFIENRKTLWSCIGDIAPAGAS
RRYWIESLDIKHLPESEQNYRLLKYGAISPVGNLRIKEATPQKAEVRYFDIEKVKDRQSDFLEYANQSGAMVGGATGAGG
EAPKLLLKRHNGKVWIDNLQDGKDQDISYLVKYPRGRYSPIDCDILRAEFHYYQEVAELGFDTIDIHHMCLEEGERYPSL
WLPRFDITKKEGKYNRLALESVYSMLQKQGGTLEHEATIRQLIKIISASNLEFDQQHFVLEWVKRDLLNIAFGNSDNHGR
NVAFLRDEQKIWLAPIYDFAPMRADPEGIIRSITWNRKGCLPQEFAGEYRFDLIAESLSDLIEPSLLLTELQQLAIRLVD
LKLRLAQRGVPQAILDHPSIGFDHLPKKLKAWGLV

Download         Length: 1308 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12284.45 Da        Isoelectric Point: 10.9810

>AT259489 WP_046098117.1 NZ_CP104917:1071496-1071822 [Avibacterium paragallinarum]
MITRKNASKVGATISTTERNNVRNRIIKALLLGKMTQGQALRKLRIEMLGVNQQQYMKMVKVSRQTLSNIENDKGNYSVE
TINQVFKPFGFELGLVPISKELLTEIMQ

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F5F0S8

References