Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2139467..2140069 Replicon chromosome
Accession NZ_CP104914
Organism Avibacterium paragallinarum strain AG21-0333

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N8E86_RS10110 Protein ID WP_017807336.1
Coordinates 2139893..2140069 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N8E86_RS10105 Protein ID WP_194743128.1
Coordinates 2139467..2139871 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E86_RS10070 (N8E86_10070) 2134536..2134868 + 333 WP_264255822.1 hypothetical protein -
N8E86_RS10075 (N8E86_10075) 2134836..2135489 - 654 WP_264255824.1 IS1595 family transposase -
N8E86_RS10080 (N8E86_10080) 2135566..2136021 + 456 WP_264255825.1 hypothetical protein -
N8E86_RS10085 (N8E86_10085) 2136018..2137454 + 1437 WP_264255827.1 DnaB-like helicase C-terminal domain-containing protein -
N8E86_RS10090 (N8E86_10090) 2137457..2138050 + 594 WP_264257063.1 phage N-6-adenine-methyltransferase -
N8E86_RS10095 (N8E86_10095) 2138040..2138465 + 426 WP_264255828.1 recombination protein NinB -
N8E86_RS10100 (N8E86_10100) 2138503..2139186 - 684 WP_264255830.1 P22AR C-terminal domain-containing protein -
N8E86_RS10105 (N8E86_10105) 2139467..2139871 - 405 WP_194743128.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N8E86_RS10110 (N8E86_10110) 2139893..2140069 - 177 WP_017807336.1 type II toxin-antitoxin system HicA family toxin Toxin
N8E86_RS10115 (N8E86_10115) 2140178..2140744 + 567 WP_264255834.1 recombination protein NinG -
N8E86_RS10120 (N8E86_10120) 2140838..2142586 + 1749 WP_264255835.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(B) - 2131539..2243247 111708
- flank IS/Tn - - 2134836..2135489 653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6714.77 Da        Isoelectric Point: 10.6249

>T259482 WP_017807336.1 NZ_CP104914:c2140069-2139893 [Avibacterium paragallinarum]
VNSKQMIKLLKQDGWYLDSINGSHHHFEHHQKKGKVTVPHPRAELGHLEKLIRKQAGL

Download         Length: 177 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14939.02 Da        Isoelectric Point: 4.7447

>AT259482 WP_194743128.1 NZ_CP104914:c2139871-2139467 [Avibacterium paragallinarum]
MLYPIALEKVTDGYVVSVPDIPGCFSAGDTLEEAYNNVKQAITSHLELVVRDNEEVPLPTPLEEHKANPDYQSVDIFFGV
IDVDISHLLGKAERINITMPAYLIKRIDDFVATHPHYKSRSHFLASVSADKIMA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References