Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1682685..1683271 Replicon chromosome
Accession NZ_CP104914
Organism Avibacterium paragallinarum strain AG21-0333

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N8E86_RS07845 Protein ID WP_264255500.1
Coordinates 1682685..1682933 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N8E86_RS07850 Protein ID WP_103853212.1
Coordinates 1682930..1683271 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E86_RS07830 (N8E86_07830) 1678711..1679910 + 1200 WP_264255497.1 tyrosine--tRNA ligase -
N8E86_RS07835 (N8E86_07835) 1680226..1681155 + 930 WP_264255498.1 aminoimidazole riboside kinase -
N8E86_RS07840 (N8E86_07840) 1681174..1682625 + 1452 WP_264255499.1 glycoside hydrolase family 32 protein -
N8E86_RS07845 (N8E86_07845) 1682685..1682933 + 249 WP_264255500.1 type II toxin-antitoxin system HicA family toxin Toxin
N8E86_RS07850 (N8E86_07850) 1682930..1683271 + 342 WP_103853212.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N8E86_RS07855 (N8E86_07855) 1683367..1683843 + 477 WP_264255501.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
N8E86_RS07860 (N8E86_07860) 1683856..1685103 + 1248 WP_264255502.1 N-acetylmuramoyl-L-alanine amidase -
N8E86_RS07865 (N8E86_07865) 1685112..1687085 + 1974 WP_264255503.1 DNA mismatch repair endonuclease MutL -
N8E86_RS07870 (N8E86_07870) 1687094..1688020 + 927 WP_264255504.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9273.95 Da        Isoelectric Point: 10.2543

>T259480 WP_264255500.1 NZ_CP104914:1682685-1682933 [Avibacterium paragallinarum]
MGKSEKLLEKLANAKNTFIWTDLLTLLTRLGYEKREMAGPRVRFYNAELDHLILLHKPHPENYIKGGALKSVKDGLKGVG
LL

Download         Length: 249 bp

>T259480 NZ_CP104914:1682685-1682933 [Avibacterium paragallinarum]
ATGGGAAAATCTGAAAAATTATTAGAAAAATTAGCTAACGCTAAAAACACCTTTATTTGGACAGATTTACTCACCTTATT
AACTCGGTTAGGCTATGAAAAACGTGAAATGGCTGGCCCTCGCGTTAGATTTTACAACGCAGAGCTTGATCACTTAATCT
TGTTACATAAACCGCACCCTGAAAATTACATCAAAGGTGGGGCGTTAAAATCAGTGAAAGATGGATTAAAAGGAGTGGGA
TTACTATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12696.47 Da        Isoelectric Point: 4.5942

>AT259480 WP_103853212.1 NZ_CP104914:1682930-1683271 [Avibacterium paragallinarum]
MTLLKYKGYVGTIEADLENNVLFGKLAYIRDVVTYEAETLPQLEKEFQTSVDLYLQDCQELGRTPDKPFKGVFNVRISEE
LHRNAVLAAGDLSLNAFVAEAIKEKVERAGITN

Download         Length: 342 bp

>AT259480 NZ_CP104914:1682930-1683271 [Avibacterium paragallinarum]
ATGACATTACTCAAATACAAAGGTTATGTCGGCACTATAGAAGCAGATTTAGAAAATAATGTGCTATTTGGCAAATTGGC
ATATATCCGAGATGTGGTTACCTATGAAGCAGAAACCTTGCCACAATTAGAGAAAGAATTTCAAACTTCTGTGGATCTGT
ATTTGCAAGATTGCCAAGAACTTGGGCGAACGCCTGACAAACCTTTCAAAGGCGTATTTAATGTGAGAATTAGCGAAGAA
CTTCACCGTAATGCCGTGTTAGCTGCGGGTGATCTTAGCTTGAATGCCTTTGTTGCCGAAGCAATTAAAGAAAAAGTAGA
GCGTGCTGGCATTACAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References