Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1444282..1445915 Replicon chromosome
Accession NZ_CP104914
Organism Avibacterium paragallinarum strain AG21-0333

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N8E86_RS06795 Protein ID WP_264255332.1
Coordinates 1444608..1445915 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N8E86_RS06790 Protein ID WP_264255330.1
Coordinates 1444282..1444608 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N8E86_RS06770 (N8E86_06770) 1439820..1440551 + 732 WP_264255325.1 class I SAM-dependent methyltransferase -
N8E86_RS06775 (N8E86_06775) 1440669..1442438 + 1770 WP_264255327.1 30S ribosomal protein S12 methylthiotransferase accessory factor YcaO -
N8E86_RS06780 (N8E86_06780) 1442527..1442949 + 423 WP_017806522.1 DUF1043 family protein -
N8E86_RS06785 (N8E86_06785) 1443111..1444241 + 1131 WP_017806521.1 class Ia ribonucleoside-diphosphate reductase subunit beta -
N8E86_RS06790 (N8E86_06790) 1444282..1444608 - 327 WP_264255330.1 helix-turn-helix domain-containing protein Antitoxin
N8E86_RS06795 (N8E86_06795) 1444608..1445915 - 1308 WP_264255332.1 HipA domain-containing protein Toxin
N8E86_RS06800 (N8E86_06800) 1446015..1446263 - 249 WP_264255333.1 class I ribonucleotide reductase maintenance protein YfaE -
N8E86_RS06805 (N8E86_06805) 1447895..1448707 - 813 WP_264246472.1 4-hydroxy-tetrahydrodipicolinate reductase -
N8E86_RS06810 (N8E86_06810) 1448722..1449357 - 636 WP_264255334.1 LysE family transporter -
N8E86_RS06815 (N8E86_06815) 1449369..1449869 - 501 WP_017806513.1 phosphatidylglycerophosphatase A -
N8E86_RS06820 (N8E86_06820) 1449875..1450909 - 1035 WP_264255335.1 thiamine-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-345)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50298.25 Da        Isoelectric Point: 5.2458

>T259479 WP_264255332.1 NZ_CP104914:c1445915-1444608 [Avibacterium paragallinarum]
MEKLTLQTYIDQEWWDMAELHFEEETYQLSNLVYFPDYITQYFGQEGSPAVSINYPVHIFIENRKALWSCIGDIAPAGAS
RRYWIESLDIKHLPESEQNYRLLKYGAISPVGNLRIKEATPQKTEVRYFDIEKVKDRQSDFLEYANQSGAMVGGATGAGG
EAPKLLLKRHNGKVWIDNLQDGKDQDISYLVKYPRGRYSPIDCDILRAEFHYYQEVAELGFDTIDIHHMCLEEGERYPSL
WLPRFDITKKEGKYNRLALESVYSMLQKQGGTLEHEATIRQLIKIISASNLEFDQQHFVLEWVKRDLLNIAFGNSDNHGR
NVAFLRDEQKIWLAPIYDFAPMRADPEGIIRSITWNRKGCLPQEFAGEYRFDLIAESLSDLIEPSLLLTELQQLAIRLVD
LKLRLAQRGVPQAILDHPSIGFNYLPEKLKAWGLV

Download         Length: 1308 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12270.38 Da        Isoelectric Point: 10.9143

>AT259479 WP_264255330.1 NZ_CP104914:c1444608-1444282 [Avibacterium paragallinarum]
MITRKNASKVGATISTTERNNVRNRIIKALLLGKMTQGQALRKLRIEMLGVNQQQYMNMVKVSRQTLSNIENDKGNYSVE
TINQVFKPFGFELGLVPISKELLTEIMQ

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References