Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 3924543..3926238 | Replicon | chromosome |
Accession | NZ_CP104913 | ||
Organism | Pseudomonas aeruginosa strain PA-AUTBAM |
Toxin (Protein)
Gene name | doc | Uniprot ID | Q9HYA0 |
Locus tag | N2X48_RS18230 | Protein ID | WP_003112901.1 |
Coordinates | 3925369..3926238 (-) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | Q9HYA1 |
Locus tag | N2X48_RS18225 | Protein ID | WP_003112902.1 |
Coordinates | 3924543..3925376 (-) | Length | 278 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
N2X48_RS18205 (N2X48_18205) | 3919774..3921258 | - | 1485 | WP_003112906.1 | aldehyde dehydrogenase | - |
N2X48_RS18210 (N2X48_18210) | 3921270..3922073 | - | 804 | WP_003112905.1 | aspartate dehydrogenase | - |
N2X48_RS18215 (N2X48_18215) | 3922084..3923766 | - | 1683 | WP_003112904.1 | thiamine pyrophosphate-binding protein | - |
N2X48_RS18220 (N2X48_18220) | 3923759..3924556 | - | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
N2X48_RS18225 (N2X48_18225) | 3924543..3925376 | - | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
N2X48_RS18230 (N2X48_18230) | 3925369..3926238 | - | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
N2X48_RS18235 (N2X48_18235) | 3926247..3926777 | - | 531 | WP_003112900.1 | cupin domain-containing protein | - |
N2X48_RS18240 (N2X48_18240) | 3926791..3927552 | - | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
N2X48_RS18245 (N2X48_18245) | 3927558..3928334 | - | 777 | WP_003112898.1 | ABC transporter permease | - |
N2X48_RS18250 (N2X48_18250) | 3928331..3929338 | - | 1008 | WP_003112897.1 | ABC transporter substrate-binding protein | - |
N2X48_RS18255 (N2X48_18255) | 3929379..3930230 | - | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T259475 WP_003112901.1 NZ_CP104913:c3926238-3925369 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT259475 WP_003112902.1 NZ_CP104913:c3925376-3924543 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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