Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3924543..3926238 Replicon chromosome
Accession NZ_CP104913
Organism Pseudomonas aeruginosa strain PA-AUTBAM

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag N2X48_RS18230 Protein ID WP_003112901.1
Coordinates 3925369..3926238 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag N2X48_RS18225 Protein ID WP_003112902.1
Coordinates 3924543..3925376 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2X48_RS18205 (N2X48_18205) 3919774..3921258 - 1485 WP_003112906.1 aldehyde dehydrogenase -
N2X48_RS18210 (N2X48_18210) 3921270..3922073 - 804 WP_003112905.1 aspartate dehydrogenase -
N2X48_RS18215 (N2X48_18215) 3922084..3923766 - 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
N2X48_RS18220 (N2X48_18220) 3923759..3924556 - 798 WP_003112903.1 SDR family oxidoreductase -
N2X48_RS18225 (N2X48_18225) 3924543..3925376 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
N2X48_RS18230 (N2X48_18230) 3925369..3926238 - 870 WP_003112901.1 alpha/beta hydrolase Toxin
N2X48_RS18235 (N2X48_18235) 3926247..3926777 - 531 WP_003112900.1 cupin domain-containing protein -
N2X48_RS18240 (N2X48_18240) 3926791..3927552 - 762 WP_003112899.1 SDR family oxidoreductase -
N2X48_RS18245 (N2X48_18245) 3927558..3928334 - 777 WP_003112898.1 ABC transporter permease -
N2X48_RS18250 (N2X48_18250) 3928331..3929338 - 1008 WP_003112897.1 ABC transporter substrate-binding protein -
N2X48_RS18255 (N2X48_18255) 3929379..3930230 - 852 WP_003130104.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T259475 WP_003112901.1 NZ_CP104913:c3926238-3925369 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT259475 WP_003112902.1 NZ_CP104913:c3925376-3924543 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References