Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3658248..3659756 Replicon chromosome
Accession NZ_CP104913
Organism Pseudomonas aeruginosa strain PA-AUTBAM

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag N2X48_RS16990 Protein ID WP_003119682.1
Coordinates 3659169..3659756 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag N2X48_RS16985 Protein ID WP_003115566.1
Coordinates 3658248..3659102 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2X48_RS16970 (N2X48_16970) 3653667..3653876 + 210 WP_003115568.1 cold-shock protein -
N2X48_RS16975 (N2X48_16975) 3653937..3655811 - 1875 WP_003091605.1 MFS transporter -
N2X48_RS16980 (N2X48_16980) 3655986..3658151 - 2166 WP_003115567.1 TonB-dependent receptor family protein -
N2X48_RS16985 (N2X48_16985) 3658248..3659102 - 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
N2X48_RS16990 (N2X48_16990) 3659169..3659756 - 588 WP_003119682.1 GNAT family protein Toxin
N2X48_RS16995 (N2X48_16995) 3660022..3663501 + 3480 WP_003114080.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T259474 WP_003119682.1 NZ_CP104913:c3659756-3659169 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT259474 WP_003115566.1 NZ_CP104913:c3659102-3658248 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References