Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2048570..2049791 | Replicon | chromosome |
| Accession | NZ_CP104913 | ||
| Organism | Pseudomonas aeruginosa strain PA-AUTBAM | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | N2X48_RS09720 | Protein ID | WP_003114949.1 |
| Coordinates | 2048570..2049148 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | N2X48_RS09725 | Protein ID | WP_003088112.1 |
| Coordinates | 2049237..2049791 (-) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N2X48_RS09705 (N2X48_09705) | 2043847..2045124 | + | 1278 | WP_003102743.1 | TolC family protein | - |
| N2X48_RS09710 (N2X48_09710) | 2045114..2047285 | + | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| N2X48_RS09715 (N2X48_09715) | 2047275..2048462 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| N2X48_RS09720 (N2X48_09720) | 2048570..2049148 | - | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| N2X48_RS09725 (N2X48_09725) | 2049237..2049791 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| N2X48_RS09730 (N2X48_09730) | 2049949..2052144 | - | 2196 | WP_003114948.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| N2X48_RS09735 (N2X48_09735) | 2052149..2052610 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| N2X48_RS09740 (N2X48_09740) | 2052941..2053264 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| N2X48_RS09745 (N2X48_09745) | 2053277..2053675 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| N2X48_RS09750 (N2X48_09750) | 2053672..2054223 | - | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T259473 WP_003114949.1 NZ_CP104913:c2049148-2048570 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT259473 WP_003088112.1 NZ_CP104913:c2049791-2049237 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|