259469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5330..5918 Replicon plasmid punamed1
Accession NZ_CP104911
Organism Acinetobacter baumannii strain YZM-0406

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag N7285_RS00030 Protein ID WP_000438826.1
Coordinates 5631..5918 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag N7285_RS00025 Protein ID WP_001983304.1
Coordinates 5330..5644 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7285_RS00005 (N7285_00005) 1158..1529 + 372 WP_000504218.1 hypothetical protein -
N7285_RS00010 (N7285_00010) 1529..1702 + 174 WP_001282484.1 hypothetical protein -
N7285_RS00015 (N7285_00015) 2025..2486 - 462 WP_000761346.1 DIP1984 family protein -
N7285_RS00020 (N7285_00020) 2791..5202 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
N7285_RS00025 (N7285_00025) 5330..5644 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
N7285_RS00030 (N7285_00030) 5631..5918 - 288 WP_000438826.1 BrnT family toxin Toxin
N7285_RS00035 (N7285_00035) 6291..6809 + 519 WP_000447193.1 tetratricopeptide repeat protein -
N7285_RS00040 (N7285_00040) 6998..7141 - 144 WP_001125246.1 hypothetical protein -
N7285_RS00045 (N7285_00045) 7161..7736 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
N7285_RS00050 (N7285_00050) 7729..8679 - 951 WP_001205343.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8731 8731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T259469 WP_000438826.1 NZ_CP104911:c5918-5631 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT259469 WP_001983304.1 NZ_CP104911:c5644-5330 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References