259468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 1000..1588 Replicon plasmid punamed2
Accession NZ_CP104910
Organism Acinetobacter baumannii strain YZM-0314

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag N7297_RS19150 Protein ID WP_000438826.1
Coordinates 1000..1287 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag N7297_RS19155 Protein ID WP_001983304.1
Coordinates 1274..1588 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7297_RS19145 (N7297_19145) 109..627 - 519 WP_000447193.1 tetratricopeptide repeat protein -
N7297_RS19150 (N7297_19150) 1000..1287 + 288 WP_000438826.1 BrnT family toxin Toxin
N7297_RS19155 (N7297_19155) 1274..1588 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
N7297_RS19160 (N7297_19160) 1716..4127 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
N7297_RS19165 (N7297_19165) 4432..4893 + 462 WP_000761346.1 DIP1984 family protein -
N7297_RS19170 (N7297_19170) 5216..5389 - 174 WP_001282484.1 hypothetical protein -
N7297_RS19175 (N7297_19175) 5389..5760 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8731 8731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T259468 WP_000438826.1 NZ_CP104910:1000-1287 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT259468 WP_001983304.1 NZ_CP104910:1274-1588 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References