259464

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 404..992 Replicon plasmid punamed1
Accession NZ_CP104906
Organism Acinetobacter baumannii strain Ab-3557

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag N7E62_RS00015 Protein ID WP_000438826.1
Coordinates 705..992 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag N7E62_RS00010 Protein ID WP_001983304.1
Coordinates 404..718 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E62_RS00010 (N7E62_00010) 404..718 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
N7E62_RS00015 (N7E62_00015) 705..992 - 288 WP_000438826.1 BrnT family toxin Toxin
N7E62_RS00020 (N7E62_00020) 1365..1883 + 519 WP_000447193.1 tetratricopeptide repeat protein -
N7E62_RS00025 (N7E62_00025) 2072..2215 - 144 WP_001125246.1 hypothetical protein -
N7E62_RS00030 (N7E62_00030) 2235..2810 - 576 WP_001096616.1 plasmid replication DNA-binding protein -
N7E62_RS00035 (N7E62_00035) 2803..3753 - 951 WP_001205343.1 replication initiation protein RepM -
N7E62_RS00040 (N7E62_00040) 4963..5334 + 372 WP_000504218.1 hypothetical protein -
N7E62_RS00045 (N7E62_00045) 5334..5507 + 174 WP_001282484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8731 8731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T259464 WP_000438826.1 NZ_CP104906:c992-705 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT259464 WP_001983304.1 NZ_CP104906:c718-404 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References