Detailed information of TA system TA025946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/-
• Location: 1583418..1583940
• Accession: NC_016810
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: SL1344_RS07705
• Protein ID: WP_000221343.1
• Coordinates: 1583418..1583702 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: SL1344_RS07710
• Protein ID: WP_000885424.1
• Coordinates: 1583692..1583940 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SL1344_RS07685 (SL1344_1475)	1579493..1581001	-	1509	WP_000199411.1	FAD-dependent oxidoreductase	-
SL1344_RS07690 (SL1344_1476)	1581046..1581534	+	489	WP_001293638.1	MarR family winged helix-turn-helix transcriptional regulator	-
SL1344_RS07695 (SL1344_1477)	1581727..1582806	+	1080	WP_000954688.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
SL1344_RS07700 (SL1344_1478)	1582858..1583247	-	390	WP_000194089.1	RidA family protein	-
SL1344_RS07705 (SL1344_1479)	1583418..1583702	-	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SL1344_RS07710 (SL1344_1480)	1583692..1583940	-	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SL1344_RS07715	1584092..1584307	+	216	WP_000206207.1	hypothetical protein	-
SL1344_RS07720 (SL1344_1481)	1584297..1584629	+	333	WP_000253154.1	DUF1493 family protein	-
SL1344_RS07725 (SL1344_1482)	1584772..1585680	+	909	WP_010989018.1	hypothetical protein	-
SL1344_RS26645 (SL1344_1483)	1585736..1586450	-	715	Protein_1509	helix-turn-helix domain-containing protein	-
SL1344_RS07740 (SL1344_1484)	1587258..1588724	-	1467	WP_000987828.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T25946 WP_000221343.1 NC_016810:c1583702-1583418 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T25946 NC_016810:c1583702-1583418 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT25946 WP_000885424.1 NC_016810:c1583940-1583692 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT25946 NC_016810:c1583940-1583692 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5