Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 2087414..2087964 Replicon chromosome
Accession NZ_CP104882
Organism Aggregatibacter actinomycetemcomitans strain IDHaas10a

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N7761_RS10240 Protein ID WP_014167746.1
Coordinates 2087698..2087964 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag N7761_RS10235 Protein ID WP_005539223.1
Coordinates 2087414..2087686 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7761_RS10215 (N7761_10215) 2083393..2084889 - 1497 WP_262088981.1 transcription termination factor NusA -
N7761_RS10220 (N7761_10220) 2084913..2085368 - 456 WP_005569409.1 ribosome maturation factor RimP -
N7761_RS10230 (N7761_10230) 2085807..2087159 + 1353 WP_005545994.1 anaerobic C4-dicarboxylate transporter DcuC -
N7761_RS10235 (N7761_10235) 2087414..2087686 + 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N7761_RS10240 (N7761_10240) 2087698..2087964 + 267 WP_014167746.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
N7761_RS10245 (N7761_10245) 2087996..2089555 + 1560 WP_005590096.1 glutamine-hydrolyzing GMP synthase -
N7761_RS10250 (N7761_10250) 2089746..2090579 + 834 WP_005590095.1 integrase arm-type DNA-binding domain-containing protein -
N7761_RS10255 (N7761_10255) 2090732..2091343 - 612 WP_005590093.1 DUF4376 domain-containing protein -
N7761_RS10260 (N7761_10260) 2091343..2092509 - 1167 WP_005590091.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10516.05 Da        Isoelectric Point: 7.2393

>T259459 WP_014167746.1 NZ_CP104882:2087698-2087964 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKIPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT259459 WP_005539223.1 NZ_CP104882:2087414-2087686 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References