259456

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1521302..1521804 Replicon chromosome
Accession NZ_CP104882
Organism Aggregatibacter actinomycetemcomitans strain IDHaas10a

Toxin (Protein)


Gene name relB Uniprot ID S4W640
Locus tag N7761_RS07610 Protein ID WP_005556313.1
Coordinates 1521302..1521556 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID X2JX79
Locus tag N7761_RS07615 Protein ID WP_005547296.1
Coordinates 1521553..1521804 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7761_RS07595 (N7761_07595) 1517235..1519409 + 2175 WP_005556309.1 DNA helicase II -
N7761_RS07600 (N7761_07600) 1519542..1520369 - 828 WP_005556311.1 DNA ligase -
N7761_RS07605 (N7761_07605) 1520546..1521289 - 744 WP_005542222.1 YdcF family protein -
N7761_RS07610 (N7761_07610) 1521302..1521556 - 255 WP_005556313.1 Txe/YoeB family addiction module toxin Toxin
N7761_RS07615 (N7761_07615) 1521553..1521804 - 252 WP_005547296.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
N7761_RS07620 (N7761_07620) 1521913..1522869 - 957 WP_005556319.1 polysaccharide pyruvyl transferase family protein -
N7761_RS07625 (N7761_07625) 1522866..1524389 - 1524 WP_053330415.1 polysaccharide biosynthesis protein -
N7761_RS07630 (N7761_07630) 1524523..1525296 + 774 WP_025298488.1 glycosyltransferase family 25 protein -
N7761_RS07635 (N7761_07635) 1525305..1526498 + 1194 WP_005556328.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10217.71 Da        Isoelectric Point: 8.8844

>T259456 WP_005556313.1 NZ_CP104882:c1521556-1521302 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9394.66 Da        Isoelectric Point: 5.0637

>AT259456 WP_005547296.1 NZ_CP104882:c1521804-1521553 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4W640

Antitoxin

Source ID Structure
AlphaFold DB X2JX79

References