Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1438360..1438894 Replicon chromosome
Accession NZ_CP104882
Organism Aggregatibacter actinomycetemcomitans strain IDHaas10a

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag N7761_RS07270 Protein ID WP_005540089.1
Coordinates 1438360..1438650 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N7761_RS07275 Protein ID WP_005545663.1
Coordinates 1438640..1438894 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7761_RS07250 (N7761_07250) 1434222..1435313 - 1092 WP_014167926.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
N7761_RS07255 (N7761_07255) 1435610..1436998 - 1389 WP_005567594.1 tRNA 5-hydroxyuridine modification protein YegQ -
N7761_RS07260 (N7761_07260) 1437169..1437621 - 453 WP_006710245.1 50S ribosomal protein L11 methyltransferase -
N7761_RS07265 (N7761_07265) 1437962..1438303 + 342 WP_014167925.1 cupin domain-containing protein -
N7761_RS07270 (N7761_07270) 1438360..1438650 - 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7761_RS07275 (N7761_07275) 1438640..1438894 - 255 WP_005545663.1 stability protein StbD Antitoxin
N7761_RS07290 (N7761_07290) 1439346..1440107 - 762 WP_005567590.1 DNA polymerase III subunit epsilon -
N7761_RS07295 (N7761_07295) 1440175..1440642 + 468 WP_005565412.1 ribonuclease HI -
N7761_RS07300 (N7761_07300) 1440730..1442061 - 1332 WP_005594223.1 3-phosphoshikimate 1-carboxyvinyltransferase -
N7761_RS07305 (N7761_07305) 1442072..1443169 - 1098 WP_005567586.1 histidinol-phosphate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T259455 WP_005540089.1 NZ_CP104882:c1438650-1438360 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9294.53 Da        Isoelectric Point: 3.9649

>AT259455 WP_005545663.1 NZ_CP104882:c1438894-1438640 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure

References