259454

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 128078..128670 Replicon chromosome
Accession NZ_CP104882
Organism Aggregatibacter actinomycetemcomitans strain IDHaas10a

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N7761_RS00625 Protein ID WP_014167707.1
Coordinates 128371..128670 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N7761_RS00620 Protein ID WP_005568148.1
Coordinates 128078..128374 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7761_RS00590 (N7761_00590) 123154..123951 - 798 WP_005568139.1 ABC transporter permease -
N7761_RS00595 (N7761_00595) 123926..124387 - 462 Protein_118 extracellular solute-binding protein -
N7761_RS00600 (N7761_00600) 124360..125163 - 804 WP_262088994.1 oxidoreductase -
N7761_RS00605 (N7761_00605) 125224..125703 + 480 WP_262088995.1 Cys-tRNA(Pro) deacylase -
N7761_RS00610 (N7761_00610) 126007..127404 - 1398 WP_005592819.1 MATE family efflux transporter -
N7761_RS00615 (N7761_00615) 127431..128045 + 615 WP_005568146.1 riboflavin synthase -
N7761_RS00620 (N7761_00620) 128078..128374 - 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
N7761_RS00625 (N7761_00625) 128371..128670 - 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7761_RS00630 (N7761_00630) 128838..129140 + 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
N7761_RS00635 (N7761_00635) 129213..129689 - 477 WP_005572298.1 transcription elongation factor GreA -
N7761_RS00640 (N7761_00640) 129849..131291 + 1443 WP_014167706.1 serine-type D-Ala-D-Ala carboxypeptidase -
N7761_RS00645 (N7761_00645) 131392..132048 - 657 WP_005568155.1 GTP cyclohydrolase I FolE -
N7761_RS00650 (N7761_00650) 132177..133391 + 1215 WP_014167705.1 molybdopterin molybdotransferase MoeA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T259454 WP_014167707.1 NZ_CP104882:c128670-128371 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT259454 WP_005568148.1 NZ_CP104882:c128374-128078 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References