259453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 90516..91185 Replicon chromosome
Accession NZ_CP104882
Organism Aggregatibacter actinomycetemcomitans strain IDHaas10a

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N7761_RS00445 Protein ID WP_005573679.1
Coordinates 90847..91185 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N7761_RS00440 Protein ID WP_014167717.1
Coordinates 90516..90797 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7761_RS00425 (N7761_00425) 86994..87476 - 483 WP_005544145.1 Dps family protein -
N7761_RS00430 (N7761_00430) 87685..88845 + 1161 WP_005545814.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
N7761_RS00435 (N7761_00435) 88855..90372 + 1518 WP_005545812.1 DHA2 family efflux MFS transporter permease subunit -
N7761_RS00440 (N7761_00440) 90516..90797 + 282 WP_014167717.1 helix-turn-helix domain-containing protein Antitoxin
N7761_RS00445 (N7761_00445) 90847..91185 + 339 WP_005573679.1 HipA N-terminal domain-containing protein Toxin
N7761_RS00450 (N7761_00450) 91179..91295 + 117 WP_005545808.1 hypothetical protein -
N7761_RS00455 (N7761_00455) 91295..91417 + 123 WP_005573281.1 hypothetical protein -
N7761_RS00460 (N7761_00460) 91414..92307 - 894 WP_005545804.1 hypothetical protein -
N7761_RS00465 (N7761_00465) 92374..95238 - 2865 WP_053330372.1 valine--tRNA ligase -
N7761_RS00470 (N7761_00470) 95322..95750 - 429 WP_080996242.1 DUF2726 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13104.85 Da        Isoelectric Point: 8.6930

>T259453 WP_005573679.1 NZ_CP104882:90847-91185 [Aggregatibacter actinomycetemcomitans]
MAKAHKWPTEFQYPPKWLDSARSRPISLSLPLSHKVYREDSVYNFFDNLLPDNEQIRSRIQQRFQTSTKSPFDLLSAIEQ
DCVGAIQLYHGESRSVRQIYAEPLNDKKCKTC

Download         Length: 339 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10508.00 Da        Isoelectric Point: 4.8356

>AT259453 WP_014167717.1 NZ_CP104882:90516-90797 [Aggregatibacter actinomycetemcomitans]
MVITTAKMLSHVIREFRYQGNLSQTDVAKLASTTQARISVFENEPERTKLETLFKILAGLELELIVQPRKKSAVTENLIS
EPTPAFSDDDEAW

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References