259436

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 354815..355731 Replicon plasmid pPA30_1
Accession NZ_CP104871
Organism Pseudomonas aeruginosa strain PA30

Toxin (Protein)


Gene name slvT Uniprot ID -
Locus tag NR803_RS34370 Protein ID WP_065760303.1
Coordinates 354815..355339 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag NR803_RS34375 Protein ID WP_019437782.1
Coordinates 355336..355731 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR803_RS34345 (NR803_034340) 350247..351332 + 1086 WP_065760307.1 sugar diacid recognition domain-containing protein -
NR803_RS34350 (NR803_034345) 351457..352602 + 1146 WP_065760306.1 glycerate kinase -
NR803_RS34355 (NR803_034350) 352682..352954 - 273 WP_065760305.1 hypothetical protein -
NR803_RS34360 (NR803_034355) 353023..353214 - 192 WP_033997860.1 hypothetical protein -
NR803_RS34365 (NR803_034360) 353519..354769 + 1251 WP_065760304.1 TerD family protein -
NR803_RS34370 (NR803_034365) 354815..355339 - 525 WP_065760303.1 RES family NAD+ phosphorylase Toxin
NR803_RS34375 (NR803_034370) 355336..355731 - 396 WP_019437782.1 hypothetical protein Antitoxin
NR803_RS34380 (NR803_034375) 356335..358218 - 1884 WP_223218642.1 helicase -
NR803_RS34385 (NR803_034380) 358418..358699 + 282 WP_065760301.1 hypothetical protein -
NR803_RS34390 (NR803_034385) 359566..360090 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / msr(E) / sul1 / blaNDM-14 / blaPER-1 / qnrVC6 / qacE / catB3 / blaOXA-1 / blaIMP-45 / tet(C) / aph(3')-Ia - 1..453250 453250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19028.50 Da        Isoelectric Point: 4.5535

>T259436 WP_065760303.1 NZ_CP104871:c355339-354815 [Pseudomonas aeruginosa]
MKIIGVQDLSCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLVSYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT259436 WP_019437782.1 NZ_CP104871:c355731-355336 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References