259434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4972920..4973560 Replicon chromosome
Accession NZ_CP104870
Organism Pseudomonas aeruginosa strain PALA9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PALA9_RS23220 Protein ID WP_003134109.1
Coordinates 4972920..4973330 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA9_RS23225 Protein ID WP_031634724.1
Coordinates 4973330..4973560 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA9_RS23180 4968446..4969243 + 798 WP_235597565.1 hypothetical protein -
PALA9_RS23185 (PALA9_04589) 4969400..4970128 + 729 WP_004352842.1 TIGR03761 family integrating conjugative element protein -
PALA9_RS23190 (PALA9_04590) 4970134..4970682 + 549 WP_004352841.1 DUF3158 family protein -
PALA9_RS23195 (PALA9_04591) 4970729..4971568 + 840 WP_003105750.1 Rha family transcriptional regulator -
PALA9_RS23200 (PALA9_04592) 4971598..4972086 + 489 WP_004352840.1 single-stranded DNA-binding protein -
PALA9_RS23205 4972242..4972409 + 168 WP_128729268.1 CrpP family ICE-associated protein -
PALA9_RS23210 (PALA9_04593) 4972475..4972693 - 219 WP_023083218.1 hypothetical protein -
PALA9_RS23215 (PALA9_04594) 4972707..4972904 - 198 WP_023083219.1 hypothetical protein -
PALA9_RS23220 (PALA9_04595) 4972920..4973330 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
PALA9_RS23225 4973330..4973560 - 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PALA9_RS23230 (PALA9_04596) 4973816..4975735 + 1920 WP_004352838.1 type I DNA topoisomerase -
PALA9_RS23235 4976043..4976252 + 210 WP_003105733.1 cold-shock protein -
PALA9_RS23240 (PALA9_04597) 4976473..4978362 + 1890 WP_003105732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4954563..5043406 88843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T259434 WP_003134109.1 NZ_CP104870:c4973330-4972920 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT259434 WP_031634724.1 NZ_CP104870:c4973560-4973330 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References