259433

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4906562..4907820 Replicon chromosome
Accession NZ_CP104870
Organism Pseudomonas aeruginosa strain PALA9

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA9_RS22845 Protein ID WP_003112528.1
Coordinates 4906562..4907317 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA9_RS22850 Protein ID WP_003086329.1
Coordinates 4907452..4907820 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA9_RS22835 (PALA9_04520) 4901735..4904278 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA9_RS22840 (PALA9_04521) 4904433..4905794 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA9_RS22845 (PALA9_04522) 4906562..4907317 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA9_RS22850 (PALA9_04523) 4907452..4907820 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA9_RS22855 (PALA9_04524) 4907893..4909179 - 1287 WP_023083139.1 FAD-binding oxidoreductase -
PALA9_RS22860 (PALA9_04525) 4909235..4910824 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA9_RS22865 (PALA9_04526) 4910903..4911379 + 477 WP_003112531.1 hypothetical protein -
PALA9_RS22870 4911382..4911657 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T259433 WP_003112528.1 NZ_CP104870:c4907317-4906562 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259433 WP_003086329.1 NZ_CP104870:c4907820-4907452 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References