Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3963838..3965059 | Replicon | chromosome |
| Accession | NZ_CP104870 | ||
| Organism | Pseudomonas aeruginosa strain PALA9 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA9_RS18395 | Protein ID | WP_003114949.1 |
| Coordinates | 3964481..3965059 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA9_RS18390 | Protein ID | WP_003088112.1 |
| Coordinates | 3963838..3964392 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA9_RS18365 (PALA9_03627) | 3959406..3959957 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| PALA9_RS18370 (PALA9_03628) | 3959954..3960352 | - | 399 | WP_023082958.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA9_RS18375 (PALA9_03629) | 3960365..3960688 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA9_RS18380 (PALA9_03630) | 3961019..3961480 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA9_RS18385 (PALA9_03631) | 3961485..3963680 | + | 2196 | WP_023082959.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA9_RS18390 (PALA9_03632) | 3963838..3964392 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA9_RS18395 (PALA9_03633) | 3964481..3965059 | + | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| PALA9_RS18400 (PALA9_03634) | 3965167..3966354 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA9_RS18405 (PALA9_03635) | 3966344..3968515 | - | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
| PALA9_RS18410 (PALA9_03636) | 3968505..3969782 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T259432 WP_003114949.1 NZ_CP104870:3964481-3965059 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT259432 WP_003088112.1 NZ_CP104870:3963838-3964392 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|