259428

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150320..150825 Replicon chromosome
Accession NZ_CP104870
Organism Pseudomonas aeruginosa strain PALA9

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag PALA9_RS00680 Protein ID WP_003121619.1
Coordinates 150320..150601 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA9_RS00685 Protein ID WP_003083775.1
Coordinates 150598..150825 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA9_RS00655 (PALA9_00128) 145571..146920 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA9_RS00660 (PALA9_00129) 146969..147655 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA9_RS00665 (PALA9_00130) 147756..148490 + 735 WP_003117208.1 GntR family transcriptional regulator -
PALA9_RS00670 (PALA9_00131) 148670..149080 + 411 WP_003101225.1 aegerolysin family protein -
PALA9_RS00675 (PALA9_00132) 149112..150020 - 909 WP_023083551.1 LysR family transcriptional regulator -
PALA9_RS00680 (PALA9_00133) 150320..150601 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
PALA9_RS00685 (PALA9_00134) 150598..150825 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA9_RS00690 (PALA9_00135) 151001..151621 - 621 WP_003101226.1 hypothetical protein -
PALA9_RS00695 (PALA9_00136) 151722..152222 + 501 WP_003101228.1 LEA type 2 family protein -
PALA9_RS00700 (PALA9_00137) 152295..152636 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA9_RS00705 (PALA9_00138) 152718..154145 - 1428 WP_003083784.1 GABA permease -
PALA9_RS00710 (PALA9_00139) 154314..155807 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T259428 WP_003121619.1 NZ_CP104870:c150601-150320 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT259428 WP_003083775.1 NZ_CP104870:c150825-150598 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References