259426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5109901..5110509 Replicon chromosome
Accession NZ_CP104869
Organism Pseudomonas aeruginosa strain PALA8

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag PALA8_RS23740 Protein ID WP_003114156.1
Coordinates 5109901..5110248 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA8_RS23745 Protein ID WP_003114155.1
Coordinates 5110258..5110509 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA8_RS23710 (PALA8_04723) 5105260..5105532 + 273 WP_003134390.1 cysteine-rich CWC family protein -
PALA8_RS23715 (PALA8_04724) 5105532..5106224 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
PALA8_RS23720 (PALA8_04725) 5106360..5107403 + 1044 WP_003134392.1 L,D-transpeptidase -
PALA8_RS23725 (PALA8_04726) 5107483..5108220 + 738 WP_003124252.1 murein L,D-transpeptidase catalytic domain family protein -
PALA8_RS23730 (PALA8_04727) 5108672..5109574 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
PALA8_RS23740 (PALA8_04729) 5109901..5110248 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA8_RS23745 5110258..5110509 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA8_RS23750 5110723..5111705 - 983 Protein_4701 tyrosine-type recombinase/integrase -
PALA8_RS23755 (PALA8_04732) 5111705..5112997 - 1293 WP_003134394.1 hypothetical protein -
PALA8_RS23760 (PALA8_04734) 5113227..5114510 - 1284 WP_023127773.1 zonular occludens toxin domain-containing protein -
PALA8_RS23765 (PALA8_04735) 5114514..5114870 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5109901..5119233 9332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T259426 WP_003114156.1 NZ_CP104869:c5110248-5109901 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT259426 WP_003114155.1 NZ_CP104869:c5110509-5110258 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References