259424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4716050..4716690 Replicon chromosome
Accession NZ_CP104869
Organism Pseudomonas aeruginosa strain PALA8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PALA8_RS21790 Protein ID WP_003134109.1
Coordinates 4716050..4716460 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA8_RS21795 Protein ID WP_031634724.1
Coordinates 4716460..4716690 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA8_RS21755 4712329..4712793 - 465 WP_154070642.1 hypothetical protein -
PALA8_RS21760 (PALA8_04336) 4713050..4713778 + 729 WP_023094843.1 TIGR03761 family integrating conjugative element protein -
PALA8_RS21765 4713784..4714319 + 536 Protein_4311 DUF3158 family protein -
PALA8_RS21770 (PALA8_04338) 4714333..4714821 + 489 WP_003134107.1 single-stranded DNA-binding protein -
PALA8_RS21775 4714926..4715120 + 195 WP_031632157.1 hypothetical protein -
PALA8_RS21780 4715372..4715539 + 168 WP_128729268.1 CrpP family ICE-associated protein -
PALA8_RS21785 (PALA8_04340) 4715840..4716034 - 195 WP_023094845.1 hypothetical protein -
PALA8_RS21790 (PALA8_04341) 4716050..4716460 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
PALA8_RS21795 4716460..4716690 - 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PALA8_RS21800 (PALA8_04342) 4717008..4718927 + 1920 WP_003134111.1 type I DNA topoisomerase -
PALA8_RS21805 (PALA8_04344) 4719109..4719687 + 579 WP_023094847.1 hypothetical protein -
PALA8_RS21810 (PALA8_04345) 4719804..4720409 - 606 WP_023094848.1 LysE family translocator -
PALA8_RS21815 (PALA8_04346) 4720531..4721400 + 870 WP_023094849.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 4698735..4817353 118618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T259424 WP_003134109.1 NZ_CP104869:c4716460-4716050 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT259424 WP_031634724.1 NZ_CP104869:c4716690-4716460 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References