Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4647305..4648563 Replicon chromosome
Accession NZ_CP104869
Organism Pseudomonas aeruginosa strain PALA8

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA8_RS21410 Protein ID WP_269973425.1
Coordinates 4647305..4648060 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA8_RS21415 Protein ID WP_003086329.1
Coordinates 4648195..4648563 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA8_RS21400 (PALA8_04265) 4642473..4645016 + 2544 WP_003134033.1 acyl-homoserine-lactone acylase QuiP -
PALA8_RS21405 (PALA8_04266) 4645171..4646532 - 1362 WP_003134034.1 DNA recombination protein RmuC -
PALA8_RS21410 (PALA8_04267) 4647305..4648060 - 756 WP_269973425.1 RES family NAD+ phosphorylase Toxin
PALA8_RS21415 (PALA8_04268) 4648195..4648563 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA8_RS21420 (PALA8_04269) 4648636..4649922 - 1287 WP_003134035.1 FAD-binding oxidoreductase -
PALA8_RS21425 4649978..4651568 - 1591 Protein_4244 aldehyde dehydrogenase family protein -
PALA8_RS21430 (PALA8_04272) 4651647..4652123 + 477 WP_003134036.1 elongation factor GreAB -
PALA8_RS21435 4652126..4652401 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28164.28 Da        Isoelectric Point: 8.0554

>T259423 WP_269973425.1 NZ_CP104869:c4648060-4647305 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQGQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259423 WP_003086329.1 NZ_CP104869:c4648563-4648195 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References