Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3692395..3693616 Replicon chromosome
Accession NZ_CP104869
Organism Pseudomonas aeruginosa strain PALA8

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PALA8_RS16910 Protein ID WP_003110488.1
Coordinates 3693038..3693616 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA8_RS16905 Protein ID WP_003132728.1
Coordinates 3692395..3692949 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA8_RS16880 (PALA8_03367) 3687961..3688512 + 552 WP_003132721.1 XRE family transcriptional regulator -
PALA8_RS16885 (PALA8_03368) 3688509..3688907 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA8_RS16890 (PALA8_03369) 3688920..3689243 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA8_RS16895 (PALA8_03370) 3689574..3690035 + 462 WP_003088117.1 (2Fe-2S)-binding protein -
PALA8_RS16900 (PALA8_03371) 3690040..3692235 + 2196 WP_023094771.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA8_RS16905 (PALA8_03372) 3692395..3692949 + 555 WP_003132728.1 helix-turn-helix transcriptional regulator Antitoxin
PALA8_RS16910 (PALA8_03373) 3693038..3693616 + 579 WP_003110488.1 HD domain-containing protein Toxin
PALA8_RS16915 (PALA8_03374) 3693726..3694913 - 1188 WP_269973392.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA8_RS16920 (PALA8_03375) 3694903..3697074 - 2172 WP_269973393.1 type I secretion system permease/ATPase -
PALA8_RS16925 (PALA8_03376) 3697064..3698341 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T259422 WP_003110488.1 NZ_CP104869:3693038-3693616 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20470.63 Da        Isoelectric Point: 8.1590

>AT259422 WP_003132728.1 NZ_CP104869:3692395-3692949 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References