Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 1649997..1651692 | Replicon | chromosome |
Accession | NZ_CP104869 | ||
Organism | Pseudomonas aeruginosa strain PALA8 |
Toxin (Protein)
Gene name | doc | Uniprot ID | - |
Locus tag | PALA8_RS07755 | Protein ID | WP_003130109.1 |
Coordinates | 1649997..1650866 (+) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | Q9HYA1 |
Locus tag | PALA8_RS07760 | Protein ID | WP_003112902.1 |
Coordinates | 1650859..1651692 (+) | Length | 278 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PALA8_RS07730 (PALA8_01541) | 1646005..1646856 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
PALA8_RS07735 (PALA8_01542) | 1646897..1647904 | + | 1008 | WP_003130107.1 | ABC transporter substrate-binding protein | - |
PALA8_RS07740 (PALA8_01543) | 1647901..1648677 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
PALA8_RS07745 (PALA8_01544) | 1648683..1649444 | + | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
PALA8_RS07750 (PALA8_01545) | 1649458..1649988 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
PALA8_RS07755 (PALA8_01546) | 1649997..1650866 | + | 870 | WP_003130109.1 | alpha/beta hydrolase | Toxin |
PALA8_RS07760 (PALA8_01547) | 1650859..1651692 | + | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
PALA8_RS07765 (PALA8_01548) | 1651679..1652476 | + | 798 | WP_003130112.1 | SDR family oxidoreductase | - |
PALA8_RS07770 (PALA8_01549) | 1652469..1654151 | + | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
PALA8_RS07775 (PALA8_01550) | 1654162..1654965 | + | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
PALA8_RS07780 (PALA8_01551) | 1654977..1656461 | + | 1485 | WP_003130118.1 | aldehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30395.67 Da Isoelectric Point: 6.8092
>T259420 WP_003130109.1 NZ_CP104869:1649997-1650866 [Pseudomonas aeruginosa]
MNMAQTHIPAPRLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHIPAPRLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT259420 WP_003112902.1 NZ_CP104869:1650859-1651692 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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