Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1649997..1651692 Replicon chromosome
Accession NZ_CP104869
Organism Pseudomonas aeruginosa strain PALA8

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PALA8_RS07755 Protein ID WP_003130109.1
Coordinates 1649997..1650866 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA8_RS07760 Protein ID WP_003112902.1
Coordinates 1650859..1651692 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA8_RS07730 (PALA8_01541) 1646005..1646856 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
PALA8_RS07735 (PALA8_01542) 1646897..1647904 + 1008 WP_003130107.1 ABC transporter substrate-binding protein -
PALA8_RS07740 (PALA8_01543) 1647901..1648677 + 777 WP_003112898.1 ABC transporter permease -
PALA8_RS07745 (PALA8_01544) 1648683..1649444 + 762 WP_003112899.1 SDR family oxidoreductase -
PALA8_RS07750 (PALA8_01545) 1649458..1649988 + 531 WP_003112900.1 cupin domain-containing protein -
PALA8_RS07755 (PALA8_01546) 1649997..1650866 + 870 WP_003130109.1 alpha/beta hydrolase Toxin
PALA8_RS07760 (PALA8_01547) 1650859..1651692 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA8_RS07765 (PALA8_01548) 1651679..1652476 + 798 WP_003130112.1 SDR family oxidoreductase -
PALA8_RS07770 (PALA8_01549) 1652469..1654151 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA8_RS07775 (PALA8_01550) 1654162..1654965 + 804 WP_003130116.1 aspartate dehydrogenase -
PALA8_RS07780 (PALA8_01551) 1654977..1656461 + 1485 WP_003130118.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30395.67 Da        Isoelectric Point: 6.8092

>T259420 WP_003130109.1 NZ_CP104869:1649997-1650866 [Pseudomonas aeruginosa]
MNMAQTHIPAPRLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT259420 WP_003112902.1 NZ_CP104869:1650859-1651692 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References