Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3623908..3625129 Replicon chromosome
Accession NZ_CP104868
Organism Pseudomonas aeruginosa strain PALA7

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA7_RS16630 Protein ID WP_003102740.1
Coordinates 3624551..3625129 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA7_RS16625 Protein ID WP_003088112.1
Coordinates 3623908..3624462 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA7_RS16600 (PALA7_03287) 3619476..3620027 + 552 WP_003102727.1 XRE family transcriptional regulator -
PALA7_RS16605 (PALA7_03288) 3620024..3620422 - 399 WP_003102731.1 NADH-quinone oxidoreductase subunit A -
PALA7_RS16610 (PALA7_03289) 3620435..3620758 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA7_RS16615 (PALA7_03290) 3621089..3621550 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA7_RS16620 (PALA7_03291) 3621555..3623750 + 2196 WP_003102738.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA7_RS16625 (PALA7_03292) 3623908..3624462 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA7_RS16630 (PALA7_03293) 3624551..3625129 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA7_RS16635 (PALA7_03294) 3625239..3626426 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA7_RS16640 (PALA7_03295) 3626416..3628587 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA7_RS16645 (PALA7_03296) 3628577..3629854 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T259415 WP_003102740.1 NZ_CP104868:3624551-3625129 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259415 WP_003088112.1 NZ_CP104868:3623908-3624462 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References