Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2574707..2575928 Replicon chromosome
Accession NZ_CP104867
Organism Pseudomonas aeruginosa strain PALA6

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA6_RS12255 Protein ID WP_003102740.1
Coordinates 2574707..2575285 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA6_RS12260 Protein ID WP_003088112.1
Coordinates 2575374..2575928 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA6_RS12240 (PALA6_02436) 2569982..2571259 + 1278 WP_003102743.1 TolC family protein -
PALA6_RS12245 (PALA6_02437) 2571249..2573420 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA6_RS12250 (PALA6_02438) 2573410..2574597 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA6_RS12255 (PALA6_02439) 2574707..2575285 - 579 WP_003102740.1 HD domain-containing protein Toxin
PALA6_RS12260 (PALA6_02440) 2575374..2575928 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA6_RS12265 (PALA6_02441) 2576086..2578281 - 2196 WP_004343108.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA6_RS12270 (PALA6_02442) 2578286..2578747 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA6_RS12275 (PALA6_02443) 2579078..2579401 + 324 WP_003162861.1 multidrug efflux SMR transporter -
PALA6_RS12280 (PALA6_02444) 2579414..2579812 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA6_RS12285 (PALA6_02445) 2579809..2580360 - 552 WP_004343115.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T259411 WP_003102740.1 NZ_CP104867:c2575285-2574707 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259411 WP_003088112.1 NZ_CP104867:c2575928-2575374 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References