Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1646989..1648247 Replicon chromosome
Accession NZ_CP104867
Organism Pseudomonas aeruginosa strain PALA6

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA6_RS07870 Protein ID WP_003163133.1
Coordinates 1647492..1648247 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA6_RS07865 Protein ID WP_003086329.1
Coordinates 1646989..1647357 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA6_RS07845 1643152..1643427 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
PALA6_RS07850 (PALA6_01561) 1643430..1643906 - 477 WP_003112531.1 hypothetical protein -
PALA6_RS07855 (PALA6_01562) 1643985..1645574 + 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA6_RS07860 (PALA6_01563) 1645630..1646916 + 1287 WP_269975482.1 FAD-binding oxidoreductase -
PALA6_RS07865 (PALA6_01564) 1646989..1647357 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA6_RS07870 (PALA6_01565) 1647492..1648247 + 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PALA6_RS07875 (PALA6_01566) 1649014..1650375 + 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA6_RS07880 (PALA6_01567) 1650530..1653073 - 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(63-207)

Antitoxin

(23-47)


Sequences


Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T259410 WP_003163133.1 NZ_CP104867:1647492-1648247 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259410 WP_003086329.1 NZ_CP104867:1646989-1647357 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References