Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/COG3657-DUF971 |
| Location | 1668464..1669053 | Replicon | chromosome |
| Accession | NC_016809 | ||
| Organism | Haemophilus influenzae 10810 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | A0A852PKG5 |
| Locus tag | HIB_RS08285 | Protein ID | WP_005662099.1 |
| Coordinates | 1668464..1668763 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | HIB_RS08290 | Protein ID | WP_015702300.1 |
| Coordinates | 1668760..1669053 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HIB_RS08245 | 1664474..1664986 | - | 513 | WP_011272619.1 | terminase small subunit | - |
| HIB_RS08250 | 1665063..1665314 | + | 252 | WP_015702292.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| HIB_RS08255 | 1665298..1665645 | + | 348 | WP_015702293.1 | helix-turn-helix domain-containing protein | - |
| HIB_RS08260 | 1665647..1665928 | - | 282 | WP_041175081.1 | hypothetical protein | - |
| HIB_RS08265 | 1665840..1666163 | - | 324 | WP_041175082.1 | DUF2570 family protein | - |
| HIB_RS08270 | 1666156..1666758 | - | 603 | WP_015702296.1 | glycoside hydrolase family 19 protein | - |
| HIB_RS08275 | 1666727..1667083 | - | 357 | WP_005650535.1 | phage holin, lambda family | - |
| HIB_RS10345 | 1667207..1667344 | - | 138 | WP_015702297.1 | hypothetical protein | - |
| HIB_RS08280 | 1667419..1668096 | - | 678 | WP_015702298.1 | hypothetical protein | - |
| HIB_RS08285 | 1668464..1668763 | + | 300 | WP_005662099.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HIB_RS08290 | 1668760..1669053 | + | 294 | WP_015702300.1 | putative addiction module antidote protein | Antitoxin |
| HIB_RS08295 | 1669085..1669453 | - | 369 | WP_015702301.1 | antitermination protein | - |
| HIB_RS08300 | 1669455..1670009 | - | 555 | WP_015702302.1 | recombination protein NinG | - |
| HIB_RS08305 | 1670012..1670215 | - | 204 | WP_015701526.1 | elongation factor Tu | - |
| HIB_RS08310 | 1670295..1670711 | - | 417 | WP_005662137.1 | recombination protein NinB | - |
| HIB_RS08315 | 1670748..1670972 | - | 225 | WP_015702303.1 | hypothetical protein | - |
| HIB_RS08320 | 1670969..1671595 | - | 627 | WP_015702304.1 | replication P | - |
| HIB_RS08325 | 1671592..1672272 | - | 681 | WP_015702305.1 | helix-turn-helix domain-containing protein | - |
| HIB_RS08330 | 1672269..1672937 | - | 669 | WP_041175131.1 | phage regulatory protein/antirepressor Ant | - |
| HIB_RS08335 | 1672929..1673234 | + | 306 | Protein_1609 | phage antirepressor KilAC domain-containing protein | - |
| HIB_RS10165 | 1673231..1673392 | + | 162 | Protein_1610 | helix-turn-helix domain-containing protein | - |
| HIB_RS08340 | 1673451..1673747 | - | 297 | WP_015702309.1 | hypothetical protein | - |
| HIB_RS08345 | 1673774..1674013 | - | 240 | WP_050792027.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1644640..1701598 | 56958 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11197.10 Da Isoelectric Point: 10.4328
>T25941 WP_005662099.1 NC_016809:1668464-1668763 [Haemophilus influenzae 10810]
MTIQIKTTLTFDSWLSKLKNLRAKAKINARIKRLQFGNFGDIKSVNDGIFELRIDEGQGYRIYLKNQNGVLVILLCGGDK
STQEKDIKQAKLLAQELGL
MTIQIKTTLTFDSWLSKLKNLRAKAKINARIKRLQFGNFGDIKSVNDGIFELRIDEGQGYRIYLKNQNGVLVILLCGGDK
STQEKDIKQAKLLAQELGL
Download Length: 300 bp
>T25941 NC_016809:1668464-1668763 [Haemophilus influenzae 10810]
ATGACAATCCAAATCAAAACCACTCTGACATTTGATTCTTGGTTAAGCAAACTAAAAAACTTGCGTGCCAAAGCGAAAAT
AAACGCACGAATTAAACGCTTACAGTTCGGCAACTTTGGTGATATCAAAAGTGTGAATGATGGGATTTTTGAATTACGGA
TTGATGAAGGTCAAGGTTATCGAATTTATCTTAAAAACCAGAATGGCGTATTAGTGATTTTACTTTGTGGCGGAGATAAA
TCCACACAAGAGAAAGATATTAAACAAGCAAAACTTCTCGCACAGGAGCTAGGATTATGA
ATGACAATCCAAATCAAAACCACTCTGACATTTGATTCTTGGTTAAGCAAACTAAAAAACTTGCGTGCCAAAGCGAAAAT
AAACGCACGAATTAAACGCTTACAGTTCGGCAACTTTGGTGATATCAAAAGTGTGAATGATGGGATTTTTGAATTACGGA
TTGATGAAGGTCAAGGTTATCGAATTTATCTTAAAAACCAGAATGGCGTATTAGTGATTTTACTTTGTGGCGGAGATAAA
TCCACACAAGAGAAAGATATTAAACAAGCAAAACTTCTCGCACAGGAGCTAGGATTATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10917.44 Da Isoelectric Point: 4.4488
>AT25941 WP_015702300.1 NC_016809:1668760-1669053 [Haemophilus influenzae 10810]
MTEQLKDFDVAEHLISEEEIQLYLNEILQEDNIELILSSLGDIARARNMSQIARDAGISREGLYKALSGTGNPTFATVMK
VMKALNLQFQVQQSRFA
MTEQLKDFDVAEHLISEEEIQLYLNEILQEDNIELILSSLGDIARARNMSQIARDAGISREGLYKALSGTGNPTFATVMK
VMKALNLQFQVQQSRFA
Download Length: 294 bp
>AT25941 NC_016809:1668760-1669053 [Haemophilus influenzae 10810]
ATGACTGAACAATTAAAAGACTTTGATGTGGCAGAACACCTCATTTCTGAAGAAGAAATTCAACTTTACCTTAATGAAAT
TCTACAAGAAGATAATATTGAGCTTATTTTATCCTCCCTTGGCGACATAGCTCGTGCGCGTAACATGAGCCAAATCGCAC
GTGATGCAGGGATAAGCCGAGAAGGTCTTTATAAAGCCTTATCTGGCACGGGCAATCCTACTTTTGCTACTGTAATGAAA
GTAATGAAAGCCTTAAATTTACAGTTCCAAGTTCAACAATCTCGATTCGCCTAA
ATGACTGAACAATTAAAAGACTTTGATGTGGCAGAACACCTCATTTCTGAAGAAGAAATTCAACTTTACCTTAATGAAAT
TCTACAAGAAGATAATATTGAGCTTATTTTATCCTCCCTTGGCGACATAGCTCGTGCGCGTAACATGAGCCAAATCGCAC
GTGATGCAGGGATAAGCCGAGAAGGTCTTTATAAAGCCTTATCTGGCACGGGCAATCCTACTTTTGCTACTGTAATGAAA
GTAATGAAAGCCTTAAATTTACAGTTCCAAGTTCAACAATCTCGATTCGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|