259409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/-
Location 1627071..1627666 Replicon chromosome
Accession NZ_CP104867
Organism Pseudomonas aeruginosa strain PALA6

Toxin (Protein)


Gene name PfiT Uniprot ID Q58CI8
Locus tag PALA6_RS07770 Protein ID WP_004348413.1
Coordinates 1627325..1627666 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID Q58CI7
Locus tag PALA6_RS07765 Protein ID WP_004348412.1
Coordinates 1627071..1627319 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA6_RS07740 (PALA6_01539) 1622255..1622506 + 252 WP_004348403.1 major capsid protein -
PALA6_RS07745 (PALA6_01540) 1622647..1623945 + 1299 Protein_1519 attachment protein -
PALA6_RS07750 (PALA6_01541) 1623949..1624305 + 357 WP_004348407.1 DUF2523 family protein -
PALA6_RS07755 (PALA6_01542) 1624309..1625458 + 1150 Protein_1521 hypothetical protein -
PALA6_RS07760 (PALA6_01544) 1625696..1626970 + 1275 WP_004348411.1 hypothetical protein -
PALA6_RS07765 (PALA6_01545) 1627071..1627319 + 249 WP_004348412.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA6_RS07770 (PALA6_01546) 1627325..1627666 + 342 WP_004348413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA6_RS07775 (PALA6_01547) 1628149..1629141 + 993 WP_004348414.1 1,2-glucosyltransferase WapB -
PALA6_RS07780 (PALA6_01548) 1629181..1629981 - 801 WP_004348415.1 IclR family transcriptional regulator -
PALA6_RS07785 (PALA6_01549) 1630139..1630525 + 387 WP_003086280.1 OB-fold domain-containing protein -
PALA6_RS07790 (PALA6_01550) 1630522..1631673 + 1152 WP_004348416.1 thiolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1612900..1629141 16241


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12942.62 Da        Isoelectric Point: 4.5106

>T259409 WP_004348413.1 NZ_CP104867:1627325-1627666 [Pseudomonas aeruginosa]
MTVREIRFTETAVFSIQDQEEHLADYHPPELAAAKIDGLIDEILTRLQDAPVGYPVSRQASDLGVTRYRELNHDGYRVLY
EAYEHENVIAVELVLRQKQDVEAALIRYCLVGI

Download         Length: 342 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9354.76 Da        Isoelectric Point: 9.6247

>AT259409 WP_004348412.1 NZ_CP104867:1627071-1627319 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLDEPMVVTQNGVPTLVVESYAERRRRDQAIALVKLLAMGSREYAEGKHCSADELKARLAKRRT
QQ

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q58CI8

Antitoxin

Source ID Structure
AlphaFold DB Q58CI7

References