Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141046..141551 Replicon chromosome
Accession NZ_CP104867
Organism Pseudomonas aeruginosa strain PALA6

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA6_RS00645 Protein ID WP_003083773.1
Coordinates 141046..141327 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA6_RS00650 Protein ID WP_003083775.1
Coordinates 141324..141551 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA6_RS00620 (PALA6_00122) 136297..137646 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA6_RS00625 (PALA6_00123) 137695..138381 + 687 WP_269975397.1 FadR/GntR family transcriptional regulator -
PALA6_RS00630 (PALA6_00124) 138482..139216 + 735 WP_004346926.1 GntR family transcriptional regulator -
PALA6_RS00635 (PALA6_00125) 139396..139806 + 411 WP_003101225.1 aegerolysin family protein -
PALA6_RS00640 (PALA6_00126) 139838..140746 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA6_RS00645 (PALA6_00127) 141046..141327 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA6_RS00650 (PALA6_00128) 141324..141551 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA6_RS00655 (PALA6_00129) 141727..142347 - 621 WP_003101226.1 hypothetical protein -
PALA6_RS00660 (PALA6_00130) 142448..142948 + 501 WP_003112629.1 LEA type 2 family protein -
PALA6_RS00665 (PALA6_00131) 143021..143362 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA6_RS00670 (PALA6_00132) 143444..144871 - 1428 WP_003121620.1 GABA permease -
PALA6_RS00675 (PALA6_00133) 145040..146533 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T259407 WP_003083773.1 NZ_CP104867:c141327-141046 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT259407 WP_003083775.1 NZ_CP104867:c141551-141324 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References