Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5546565..5547151 Replicon chromosome
Accession NZ_CP104866
Organism Pseudomonas aeruginosa strain PALA4

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PALA4_RS25820 Protein ID WP_003120987.1
Coordinates 5546852..5547151 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PALA4_RS25815 Protein ID WP_003448662.1
Coordinates 5546565..5546855 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA4_RS25795 (PALA4_05101) 5542159..5544036 + 1878 WP_023911870.1 hypothetical protein -
PALA4_RS25800 (PALA4_05102) 5544033..5546009 + 1977 WP_031275715.1 DEAD/DEAH box helicase -
PALA4_RS25805 5546019..5546153 + 135 WP_033179080.1 hypothetical protein -
PALA4_RS25810 5546150..5546494 + 345 WP_003448665.1 hypothetical protein -
PALA4_RS25815 (PALA4_05103) 5546565..5546855 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PALA4_RS25820 5546852..5547151 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA4_RS25825 (PALA4_05104) 5547352..5548476 + 1125 WP_023435880.1 TcpQ domain-containing protein -
PALA4_RS25830 (PALA4_05105) 5548476..5550185 + 1710 WP_023435879.1 PilN family type IVB pilus formation outer membrane protein -
PALA4_RS25835 (PALA4_05106) 5550189..5551514 + 1326 WP_023435878.1 type 4b pilus protein PilO2 -
PALA4_RS25840 (PALA4_05107) 5551504..5552037 + 534 WP_023435877.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5522260..5621662 99402


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T259405 WP_003120987.1 NZ_CP104866:c5547151-5546852 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT259405 WP_003448662.1 NZ_CP104866:c5546855-5546565 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References