Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 5429081..5429718 Replicon chromosome
Accession NZ_CP104866
Organism Pseudomonas aeruginosa strain PALA4

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PALA4_RS25270 Protein ID WP_019725766.1
Coordinates 5429536..5429718 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PALA4_RS25265 Protein ID WP_019725767.1
Coordinates 5429081..5429503 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA4_RS25240 (PALA4_04991) 5425255..5425731 + 477 WP_023122758.1 phage tail assembly chaperone -
PALA4_RS25245 (PALA4_04992) 5425728..5426651 + 924 WP_023122759.1 hypothetical protein -
PALA4_RS25250 (PALA4_04993) 5426648..5427190 + 543 WP_023122760.1 hypothetical protein -
PALA4_RS25255 (PALA4_04994) 5427187..5427879 + 693 WP_023122761.1 hypothetical protein -
PALA4_RS25260 (PALA4_04995) 5427864..5428835 + 972 WP_023122762.1 hypothetical protein -
PALA4_RS25265 (PALA4_04997) 5429081..5429503 - 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PALA4_RS25270 (PALA4_04998) 5429536..5429718 - 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
PALA4_RS25275 (PALA4_04999) 5430249..5431181 - 933 WP_003120918.1 ZIP family metal transporter -
PALA4_RS25280 (PALA4_05000) 5431200..5431811 - 612 WP_003098862.1 superoxide dismutase -
PALA4_RS25285 (PALA4_05001) 5431824..5432273 - 450 WP_003094369.1 hypothetical protein -
PALA4_RS25290 (PALA4_05002) 5432301..5433677 - 1377 WP_003098863.1 class II fumarate hydratase FumC -
PALA4_RS25295 (PALA4_05003) 5433670..5434065 - 396 WP_003094374.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T259404 WP_019725766.1 NZ_CP104866:c5429718-5429536 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT259404 WP_019725767.1 NZ_CP104866:c5429503-5429081 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References