Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4788934..4790192 Replicon chromosome
Accession NZ_CP104866
Organism Pseudomonas aeruginosa strain PALA4

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PALA4_RS22195 Protein ID WP_003086331.1
Coordinates 4788934..4789689 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA4_RS22200 Protein ID WP_003086329.1
Coordinates 4789824..4790192 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA4_RS22185 (PALA4_04386) 4784103..4786646 + 2544 WP_003108653.1 acyl-homoserine-lactone acylase QuiP -
PALA4_RS22190 (PALA4_04387) 4786801..4788162 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA4_RS22195 (PALA4_04388) 4788934..4789689 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PALA4_RS22200 (PALA4_04389) 4789824..4790192 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA4_RS22205 (PALA4_04390) 4790265..4791551 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA4_RS22210 (PALA4_04391) 4791607..4793196 - 1590 WP_022580156.1 aldehyde dehydrogenase family protein -
PALA4_RS22215 (PALA4_04392) 4793274..4793750 + 477 WP_009877993.1 elongation factor GreAB -
PALA4_RS22220 4793753..4794028 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T259403 WP_003086331.1 NZ_CP104866:c4789689-4788934 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259403 WP_003086329.1 NZ_CP104866:c4790192-4789824 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References