Detailed information of TA system TA259399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1758184..1759692
• Replicon: chromosome
• Accession: NZ_CP104866
• Organism: Pseudomonas aeruginosa strain PALA4

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PALA4_RS08085
• Protein ID: WP_023443480.1
• Coordinates: 1758184..1758771 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: PALA4_RS08090
• Protein ID: WP_003109159.1
• Coordinates: 1758838..1759692 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PALA4_RS08080 (PALA4_01601)	1754439..1757918	-	3480	WP_003091610.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
PALA4_RS08085 (PALA4_01602)	1758184..1758771	+	588	WP_023443480.1	GNAT family protein	Toxin
PALA4_RS08090 (PALA4_01603)	1758838..1759692	+	855	WP_003109159.1	AraC family transcriptional regulator	Antitoxin
PALA4_RS08095 (PALA4_01604)	1759789..1761954	+	2166	WP_003109160.1	TonB-dependent receptor family protein	-
PALA4_RS08100 (PALA4_01605)	1762129..1764003	+	1875	WP_003091605.1	MFS transporter	-
PALA4_RS08105 (PALA4_01606)	1764064..1764273	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21931.26 Da
• Isoelectric Point: 9.8676

>T259399 WP_023443480.1 NZ_CP104866:1758184-1758771 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRTLPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31842.15 Da
• Isoelectric Point: 7.3168

>AT259399 WP_003109159.1 NZ_CP104866:1758838-1759692 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRCATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Nucleotide

• Length: 855 bp