Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 711050..712270 Replicon chromosome
Accession NZ_CP104866
Organism Pseudomonas aeruginosa strain PALA4

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PALA4_RS03285 Protein ID WP_003110488.1
Coordinates 711050..711628 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA4_RS03290 Protein ID WP_003088112.1
Coordinates 711716..712270 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA4_RS03270 (PALA4_00654) 706325..707602 + 1278 WP_003110491.1 TolC family protein -
PALA4_RS03275 (PALA4_00655) 707592..709763 + 2172 WP_003110490.1 type I secretion system permease/ATPase -
PALA4_RS03280 (PALA4_00656) 709753..710940 + 1188 WP_003110489.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA4_RS03285 (PALA4_00657) 711050..711628 - 579 WP_003110488.1 HD domain-containing protein Toxin
PALA4_RS03290 (PALA4_00658) 711716..712270 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA4_RS03295 (PALA4_00659) 712428..714623 - 2196 WP_003110487.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA4_RS03300 (PALA4_00660) 714628..715089 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA4_RS03305 (PALA4_00661) 715420..715743 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA4_RS03310 (PALA4_00662) 715756..716154 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA4_RS03315 716151..716701 - 551 Protein_655 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T259398 WP_003110488.1 NZ_CP104866:c711628-711050 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259398 WP_003088112.1 NZ_CP104866:c712270-711716 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References