Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 146702..147207 Replicon chromosome
Accession NZ_CP104866
Organism Pseudomonas aeruginosa strain PALA4

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA4_RS00675 Protein ID WP_003083773.1
Coordinates 146702..146983 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA4_RS00680 Protein ID WP_003083775.1
Coordinates 146980..147207 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA4_RS00650 (PALA4_00129) 141953..143302 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PALA4_RS00655 (PALA4_00130) 143351..144037 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA4_RS00660 (PALA4_00131) 144138..144872 + 735 WP_003110658.1 GntR family transcriptional regulator -
PALA4_RS00665 (PALA4_00132) 145052..145462 + 411 WP_003110659.1 aegerolysin family protein -
PALA4_RS00670 (PALA4_00133) 145494..146402 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA4_RS00675 (PALA4_00134) 146702..146983 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA4_RS00680 (PALA4_00135) 146980..147207 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA4_RS00685 (PALA4_00136) 147383..148003 - 621 WP_003101226.1 hypothetical protein -
PALA4_RS00690 (PALA4_00137) 148104..148604 + 501 WP_003101228.1 LEA type 2 family protein -
PALA4_RS00695 (PALA4_00138) 148677..149018 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA4_RS00700 (PALA4_00139) 149100..150527 - 1428 WP_003083784.1 GABA permease -
PALA4_RS00705 (PALA4_00140) 150696..152189 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T259396 WP_003083773.1 NZ_CP104866:c146983-146702 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT259396 WP_003083775.1 NZ_CP104866:c147207-146980 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References