259394

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/-
Location 4285670..4286265 Replicon chromosome
Accession NZ_CP104865
Organism Pseudomonas aeruginosa strain PALA2

Toxin (Protein)


Gene name PfiT Uniprot ID Q58CI8
Locus tag PALA2_RS19870 Protein ID WP_004348413.1
Coordinates 4285670..4286011 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID Q58CI7
Locus tag PALA2_RS19875 Protein ID WP_004348412.1
Coordinates 4286017..4286265 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA2_RS19850 (PALA2_03953) 4281663..4282814 - 1152 WP_004348416.1 thiolase -
PALA2_RS19855 (PALA2_03954) 4282811..4283197 - 387 WP_003086280.1 OB-fold domain-containing protein -
PALA2_RS19860 (PALA2_03955) 4283355..4284155 + 801 WP_004348415.1 IclR family transcriptional regulator -
PALA2_RS19865 (PALA2_03956) 4284195..4285187 - 993 WP_004348414.1 1,2-glucosyltransferase WapB -
PALA2_RS19870 (PALA2_03957) 4285670..4286011 - 342 WP_004348413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA2_RS19875 (PALA2_03958) 4286017..4286265 - 249 WP_004348412.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA2_RS19880 (PALA2_03959) 4286366..4287640 - 1275 WP_004348411.1 hypothetical protein -
PALA2_RS19885 (PALA2_03961) 4287878..4289027 - 1150 Protein_3936 hypothetical protein -
PALA2_RS19890 (PALA2_03962) 4289031..4289387 - 357 WP_004348407.1 DUF2523 family protein -
PALA2_RS19895 (PALA2_03963) 4289391..4290689 - 1299 Protein_3938 attachment protein -
PALA2_RS19900 (PALA2_03964) 4290830..4291081 - 252 WP_004348403.1 major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4284195..4300436 16241


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12942.62 Da        Isoelectric Point: 4.5106

>T259394 WP_004348413.1 NZ_CP104865:c4286011-4285670 [Pseudomonas aeruginosa]
MTVREIRFTETAVFSIQDQEEHLADYHPPELAAAKIDGLIDEILTRLQDAPVGYPVSRQASDLGVTRYRELNHDGYRVLY
EAYEHENVIAVELVLRQKQDVEAALIRYCLVGI

Download         Length: 342 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9354.76 Da        Isoelectric Point: 9.6247

>AT259394 WP_004348412.1 NZ_CP104865:c4286265-4286017 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLDEPMVVTQNGVPTLVVESYAERRRRDQAIALVKLLAMGSREYAEGKHCSADELKARLAKRRT
QQ

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q58CI8

Antitoxin

Source ID Structure
AlphaFold DB Q58CI7

References