Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4265089..4266347 Replicon chromosome
Accession NZ_CP104865
Organism Pseudomonas aeruginosa strain PALA2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA2_RS19770 Protein ID WP_003163133.1
Coordinates 4265089..4265844 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA2_RS19775 Protein ID WP_003086329.1
Coordinates 4265979..4266347 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA2_RS19760 (PALA2_03936) 4260263..4262806 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
PALA2_RS19765 (PALA2_03937) 4262961..4264322 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA2_RS19770 (PALA2_03938) 4265089..4265844 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PALA2_RS19775 (PALA2_03939) 4265979..4266347 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA2_RS19780 (PALA2_03940) 4266420..4267706 - 1287 WP_023096923.1 FAD-binding oxidoreductase -
PALA2_RS19785 (PALA2_03941) 4267762..4269351 - 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
PALA2_RS19790 (PALA2_03942) 4269430..4269906 + 477 WP_003112531.1 hypothetical protein -
PALA2_RS19795 4269909..4270184 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T259393 WP_003163133.1 NZ_CP104865:c4265844-4265089 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT259393 WP_003086329.1 NZ_CP104865:c4266347-4265979 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References