Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2839136..2840357 Replicon chromosome
Accession NZ_CP104865
Organism Pseudomonas aeruginosa strain PALA2

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA2_RS13430 Protein ID WP_003102740.1
Coordinates 2839136..2839714 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA2_RS13435 Protein ID WP_003088112.1
Coordinates 2839803..2840357 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA2_RS13415 (PALA2_02676) 2834411..2835688 + 1278 WP_003102743.1 TolC family protein -
PALA2_RS13420 (PALA2_02677) 2835678..2837849 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA2_RS13425 (PALA2_02678) 2837839..2839026 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA2_RS13430 (PALA2_02679) 2839136..2839714 - 579 WP_003102740.1 HD domain-containing protein Toxin
PALA2_RS13435 (PALA2_02680) 2839803..2840357 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA2_RS13440 (PALA2_02681) 2840515..2842710 - 2196 WP_004343108.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA2_RS13445 (PALA2_02682) 2842715..2843176 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA2_RS13450 (PALA2_02683) 2843507..2843830 + 324 WP_003162861.1 multidrug efflux SMR transporter -
PALA2_RS13455 (PALA2_02684) 2843843..2844241 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA2_RS13460 (PALA2_02685) 2844238..2844789 - 552 WP_004343115.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T259392 WP_003102740.1 NZ_CP104865:c2839714-2839136 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT259392 WP_003088112.1 NZ_CP104865:c2840357-2839803 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References