259391

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1800670..1802178 Replicon chromosome
Accession NZ_CP104865
Organism Pseudomonas aeruginosa strain PALA2

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag PALA2_RS08360 Protein ID WP_003119682.1
Coordinates 1800670..1801257 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag PALA2_RS08365 Protein ID WP_003117606.1
Coordinates 1801324..1802178 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA2_RS08355 (PALA2_01659) 1796925..1800404 - 3480 WP_004345049.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
PALA2_RS08360 (PALA2_01660) 1800670..1801257 + 588 WP_003119682.1 GNAT family protein Toxin
PALA2_RS08365 (PALA2_01661) 1801324..1802178 + 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
PALA2_RS08370 (PALA2_01662) 1802275..1804440 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
PALA2_RS08375 (PALA2_01663) 1804615..1806489 + 1875 WP_003117607.1 MFS transporter -
PALA2_RS08380 (PALA2_01664) 1806550..1806759 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T259391 WP_003119682.1 NZ_CP104865:1800670-1801257 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT259391 WP_003117606.1 NZ_CP104865:1801324-1802178 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References