Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143486..143991 Replicon chromosome
Accession NZ_CP104865
Organism Pseudomonas aeruginosa strain PALA2

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA2_RS00655 Protein ID WP_003083773.1
Coordinates 143486..143767 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA2_RS00660 Protein ID WP_003083775.1
Coordinates 143764..143991 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA2_RS00630 (PALA2_00124) 138737..140086 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA2_RS00635 (PALA2_00125) 140135..140821 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA2_RS00640 (PALA2_00126) 140922..141656 + 735 WP_004346926.1 GntR family transcriptional regulator -
PALA2_RS00645 (PALA2_00127) 141836..142246 + 411 WP_003101225.1 aegerolysin family protein -
PALA2_RS00650 (PALA2_00128) 142278..143186 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA2_RS00655 (PALA2_00129) 143486..143767 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA2_RS00660 (PALA2_00130) 143764..143991 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA2_RS00665 (PALA2_00131) 144167..144787 - 621 WP_003101226.1 hypothetical protein -
PALA2_RS00670 (PALA2_00132) 144888..145388 + 501 WP_003112629.1 LEA type 2 family protein -
PALA2_RS00675 (PALA2_00133) 145461..145802 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA2_RS00680 (PALA2_00134) 145884..147311 - 1428 WP_003121620.1 GABA permease -
PALA2_RS00685 (PALA2_00135) 147480..148973 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T259390 WP_003083773.1 NZ_CP104865:c143767-143486 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT259390 WP_003083775.1 NZ_CP104865:c143991-143764 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References