Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1115215..1115846 Replicon chromosome
Accession NC_016809
Organism Haemophilus influenzae 10810

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag HIB_RS05725 Protein ID WP_005651560.1
Coordinates 1115215..1115613 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2X4XKC3
Locus tag HIB_RS05730 Protein ID WP_015701961.1
Coordinates 1115613..1115846 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIB_RS05705 1110399..1111517 + 1119 WP_015701957.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
HIB_RS05710 1111518..1112540 + 1023 WP_015701958.1 outer membrane-stress sensor serine endopeptidase DegS -
HIB_RS05715 1112614..1113429 - 816 WP_015701959.1 DNA-formamidopyrimidine glycosylase -
HIB_RS05720 1113660..1115195 - 1536 WP_015701960.1 L-2,4-diaminobutyrate decarboxylase -
HIB_RS05725 1115215..1115613 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
HIB_RS05730 1115613..1115846 - 234 WP_015701961.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
HIB_RS05735 1115993..1117357 - 1365 WP_015701962.1 diaminobutyrate--2-oxoglutarate transaminase -
HIB_RS05740 1117704..1117874 - 171 WP_005613503.1 50S ribosomal protein L33 -
HIB_RS05745 1117886..1118122 - 237 WP_005542826.1 50S ribosomal protein L28 -
HIB_RS05750 1118336..1119001 - 666 WP_013527272.1 DNA repair protein RadC -
HIB_RS05755 1119164..1120366 + 1203 WP_015701964.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T25939 WP_005651560.1 NC_016809:c1115613-1115215 [Haemophilus influenzae 10810]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T25939 NC_016809:c1115613-1115215 [Haemophilus influenzae 10810]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8911.01 Da        Isoelectric Point: 4.4013

>AT25939 WP_015701961.1 NC_016809:c1115846-1115613 [Haemophilus influenzae 10810]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQTVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT25939 NC_016809:c1115846-1115613 [Haemophilus influenzae 10810]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTGTCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAACAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XKC3

References